Jill & Alan Miller Endowed Chair in Breast Cancer Excellence
Professor of Medicine
Co-Leader, Breast Cancer Program, Abramson Cancer Center
Co-Director, 2-PREVENT Translational Center of Excellence
Physician Lead, Breast Cancer Clinical Research Unit
Perelman School of Medicine, University of Pennsylvania
Philadelphia, PA
Dr. DeMichele holds the Jill and Alan Miller Endowed Chair in Breast Cancer Excellence, and is a Professor of Medicine and Epidemiology at the University of Pennsylvania. She is the Co-Leader of the Breast Cancer Research Program in the Abramson Cancer Center and Co-Directs the 2-PREVENT Translational Center of Excellence. Dr. DeMichele earned a B.S. in Biochemistry from Brown University, an M.D. from Washington University School of Medicine (as a Four Schools Physician-Scientist Scholar) and a Master’s Degree in Clinical Epidemiology from the University of Pennsylvania, where she also received clinical training in Internal Medicine and Hematology/Oncology. Nationally, she serves on the NCI Breast Cancer Steering Committee, the Executive Committee of AACR’s San Antonio Breast Cancer Symposium, is the Co-Chair of the Breast Committee of the ECOG-ACRIN Cooperative Group, and chairs the ISPY2 Clinical Trial Operations Working Group. She also serves on breast cancer guideline committees for the NCCN, American Society of Clinical Oncology (ASCO) and European Society of Clinical Oncology (ESMO). She is an Associate Editor at Nature NPJ Breast Cancer, and has served on the American Board of Internal Medicine Oncology Subspecialty Board, and numerous editorial boards, including the Journal of Clinical Oncology. She previously chaired ASCO’s Breast Cancer Education and Program Committees. From 2000-2015, she also was a Senior Scholar in the Center for Clinical Epidemiology and Biostatistics, and during that time, from 2008–2013, she directed the Doris Duke Clinical Research Fellowship Program at the University of Pennsylvania, where she oversaw the year-out research experience of medical students from around the United States.
Since joining the faculty of the University of Pennsylvania in 2000, Dr. DeMichele’s research has focused exclusively on developing novel therapeutics and breast cancer biomarkers. She is a past recipient of a Young Investigator Award from the American Society of Clinical Oncology, a Clinical Research Training Grant from the American Cancer Society and a Patient-Oriented Career Development Award (K23) from the NIH. Dr. DeMichele is an experienced clinical trialist who has been Principal Investigator of numerous investigator-initiated clinical trials. (IITs), site PI of over 30 industry and cooperative group trials, is the Penn Site PI for the Translational Breast Cancer Research Consortium and is a member of the Breast Committee in the Eastern Cooperative Oncology Group. She currently serves as Co-Principal Investigator of the Palbociclib international cooperative group adjuvant trial (PALLAS), having been instrumental in both the phase I trial of this compound and PI of the single agent phase II trial in breast cancer. She is on the Steering Committees of several additional multicenter and international clinical trials, evaluating CDK 4/6 inhibitors, JAK inhibitors and other agents in breast cancer.
